MOLECULAR MARKERS OF CANCER CERVIX

Sidorenko Ekaterina Gennadyevna, Postgraduate student, Institute of medicine, ecology and physical culture, Ulyanovsk State University, nikolaenkova73@mail.ru
Antoneeva Inna Ivanovna, Doctor of medical sciences, associate professor, sub-department of oncology and radiodiagnostics, Institute of medicine, ecology and physical culture, Ulyanovsk State University, aii72@mail.ru
Gening Tatyana Petrovna, Doctor of biological sciences, professor, head of sub-department of physiology and pathophysiology, Ulyanovsk State University, Naum-53@yandex.ru
Arslanova Dinara Rishatovna, Candidate of biological sciences, senior staff scientist, Ulyanovsk State University, monika_rainbow@mail.ru
Abakumova Tatyana Vladimirovna, Candidate of biological sciences, senior staff scientist, Ulyanovsk State University, taty-abakumova@yandex.ru

 616-006:616-018

In the course of immunohistochemical research the authors have determined the level of expression of р53 and Bcl-2 biomolecular markers and the epidermal factor of growth in operational-biopsy preparations for 45 patients with cervical cancer at various clinical stages of the disease. It is revealed that the expression of the epidermal factor of growth is uncommon, the expression of p53 intensifies in epithelia and decreases in a stroma subject to cervical cancer progression. The ex-pression of Bcl-2 rises in a stroma and an epithelium at the stage Ib–IIa. Definition of the expression level of the given markers has an undoubtable practical value for estimation of a biological portrait of a tumor at cervical cancer in dynamics of tu-moral progression.

biomolecular markers, cervical cancer, tumor progression.